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Cefuroxime Axetil API Powder is a semi-synthetic, second-generation cephalosporin antibiotic used widely in the pharmaceutical industry for the production of oral antibacterial drugs. It is formulated as the axetil ester prodrug of cefuroxime, enhancing oral bioavailability, and is effective against a broad spectrum of gram-positive and gram-negative bacteria.

 

Key Product Features:

• Form: White or almost white powder, often in the amorphous form.

• Grade: Pharmaceutical grade—meets BP/EP/USP/IP standards.

• Purity: Typically greater than 99%.

• CAS Number: 64544-07-6.

• Molecular Formula: C20H22N4O10S.

• Molecular Weight: 510.47 g/mol.

• Packaging: Commonly supplied in 25 kg drums.

• Storage: Store in a cool, dry place to protect from moisture.

Pharmacological Profile:

• Class: Second-generation cephalosporin; β-lactam antibiotic.

• Mechanism: Bactericidal—acts by inhibiting bacterial cell wall synthesis.

• Prodrug Status: Axetil ester is hydrolyzed after oral administration to release active cefuroxime.

• β-lactamase Resistance: More resistant to β-lactamases compared to first-generation cephalosporins, covering more pathogens.

Therapeutic Uses:

• Indicated for treating infections caused by susceptible bacteria, especially:

  • Respiratory tract infections (e.g., pharyngitis, tonsillitis, sinusitis, bronchitis, pneumonia).

  • Skin and soft tissue infections.

  • Urinary tract infections.

  • Acute otitis media.

  • Uncomplicated gonorrhea and cervicitis.

• Acts against: Hemolytic streptococcus, Staphylococcus aureus (excluding MRSA), Haemophilus influenzae, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, and other susceptible Enterobacteriaceae.

Summary Table: Cefuroxime Axetil API Powder

Cefuroxime Axetil API powder is primarily used in the pharmaceutical industry for formulation of oral antibiotics, providing a broad-spectrum, reliable treatment for various bacterial infections in both adult and pediatric populations

Telmisartan is a selective angiotensin II receptor blocker (ARB) used as an active pharmaceutical ingredient (API) in antihypertensive medications. It helps lower blood pressure by relaxing blood vessels and is also used to reduce cardiovascular risk in patients with high blood pressure or certain heart conditions.

Key Features:

• Chemical Name: 4'-[[4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl][1,1'-biphenyl]-2-carboxylic acid

• Molecular Formula: C33H30N4O2

• Molecular Weight: 514.62 g/mol.

• CAS Number: 144701-48-4.

• Appearance: White or off-white crystalline powder; odorless and tasteless.

• Purity (Assay): 99.0% ~ 101.0%.

• Melting Point: 261–263°C.

• Solubility:

  • Practically insoluble in water

  • Soluble in chloroform

  • Slightly soluble in methanol, very slightly in acetone

  • Slightly soluble in 0.1 mol/L hydrochloric acid, soluble in 0.1 mol/L sodium hydroxide.

• Stability: Hygroscopic; should be stored at 2–8°C, protected from moisture and light.

• Particle Size and Polymorphism: Controlled as critical parameters for bioavailability and product stability.

Pharmacological Profile and Uses:

• Class: Angiotensin II receptor blocker (ARB).

• Therapeutic Use: Used in the treatment of hypertension, heart failure, and for reducing the risk of heart attack and stroke.

• Mechanism of Action: Blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and resulting in vasodilation and reduced blood pressure.

• Regulatory Grade: Meets pharmacopoeial standards (USP, BP, EP).

Quality Specifications:

• Loss on Drying: Not more than 0.5%.

• Heavy Metals: Not more than 20 ppm.

• Residue on Ignition: Not more than 0.1%.

Packaging and Storage:

• Packaging: Usually provided in 25 kg fiber drums or equivalent bulk containers.

• Shelf Life: Up to 36 months when stored appropriately.

• Storage Conditions: Store in a tightly closed container, protected from moisture, at controlled room temperature or 2–8°C

Spectinomycin Powder API is a pharmaceutical-grade aminocyclitol antibiotic primarily produced by Streptomyces spectabilis and used for the treatment of bacterial infections, especially those caused by Neisseria gonorrhoeae. It is commonly supplied as a white to off-white crystalline or granular powder, available in forms including Spectinomycin base, hydrochloride (HCl), or sulfate salts.

Key Features:

• Chemical Class: Aminocyclitol antibiotic (structurally related to aminoglycosides but lacks amino sugar and glycosidic bonds)

• Molecular Formula and Weight:

  • Spectinomycin Sulfate: C14H34N2O14S, MW ~446 g/mol

  • Spectinomycin Hydrochloride: C14H36Cl2N2O12, MW ~495 g/mol

• Appearance: White or almost white powder, slightly hygroscopic

• Solubility: Freely soluble in water, almost insoluble in ethanol and organic solvents

• Pharmacological Action:

  • Bactericidal inhibitor of bacterial protein synthesis by binding to the 30S ribosomal subunit

  • Acts specifically against gram-negative bacteria like Neisseria gonorrhoeae

• Primary Indications:

  • Treatment of acute gonorrheal urethritis, cervicitis, and proctitis caused by susceptible strains of Neisseria gonorrhoeae, especially penicillin-resistant strains

  • Used in patients allergic to penicillin or when other antibiotics are inappropriate

• Formulations: Used to manufacture injectable solutions primarily, due to poor oral bioavailability

• Stability and Packaging:

  • Usually packaged in 10–25 kg fiber or cardboard drums with moisture protection

  • Stable when stored under cool, dry conditions away from light and moisture

• Regulatory Status: Produced in GMP-certified facilities, with available DMF and COA documentation

Summary Table: Spectinomycin Powder API

Note:
Spectinomycin API powder is intended strictly for pharmaceutical manufacturing of sterile injectable formulations. It is not suitable for direct oral administration or consumer use without appropriate formulation and medical supervision.

Metformin Hydrochloride (Metformin HCl) API Powder is a widely used active pharmaceutical ingredient primarily formulated into oral antidiabetic medications. It is the first-line therapy for type 2 diabetes mellitus due to its well-documented ability to lower blood sugar levels safely and effectively.

 

Key Features:

• Chemical Name: Metformin Hydrochloride

• Synonyms: 1,1-Dimethylbiguanide hydrochloride, N,N-Dimethylimidodicarbonimidic diamide hydrochloride

• CAS Number: 1115-70-4

• Molecular Formula: C4H12ClN5

• Molecular Weight: 165.62 g/mol

• Appearance: White crystalline powder

• Purity (Assay): 98.5–101.0% (typically ≥99%)

• Melting Point: 216–226°C

• Solubility: Freely soluble in water, slightly soluble in alcohol

• pH (1% solution): 5.5–7.0

• Grade: USP/EP/BP/IP; pharmaceutical grade

• Packaging: Commonly supplied in 25 kg fiber drums with protective inner liners

• Shelf Life: 3–5 years when stored in cool, dry conditions (typically at -20°C for long-term stability)

Pharmacological Profile & Uses:

• Therapeutic Category: Oral hypoglycemic, biguanide class

• Mechanism of Action:

  • Lowers hepatic glucose production

  • Increases insulin sensitivity

  • Decreases intestinal absorption of glucose

• Primary Use: Active ingredient in oral medications for the treatment and management of type 2 diabetes mellitus; also investigated for use in polycystic ovary syndrome (PCOS), anti-aging research, and as adjunct therapy in other metabolic conditions.

Quality Specifications (typical values):

Storage & Handling:

• Store in a cool, dry place away from moisture and light.

• Keep container tightly closed.

• Shelf life is typically 3–5 years under recommended storage conditions.

Application:
Metformin HCl API powder is intended exclusively for pharmaceutical manufacturing and is not for direct human consumption. It is a core ingredient in most generic and branded metformin tablets and oral solutions globally

Lincomycin Hydrochloride (Lincomycin HCl) API Powder is a pharmaceutical-grade antibiotic active pharmaceutical ingredient widely used in medical and veterinary fields for the treatment of infections caused by susceptible bacteria. It is produced by fermentation of Streptomyces lincolnensis and belongs to the lincosamide class of antibiotics.

Key Features:

• Chemical Name: Lincomycin Hydrochloride

• CAS Number: 859-18-7

• Molecular Formula: C18H34N2O6S · HCl

• Molecular Weight: Approximately 443 g/mol

• Appearance: White to off-white crystalline powder, practically odorless or having a faint odor

• Purity: Typically ranges between 96% and 102% as per pharmacopeial standards

• Solubility: Freely soluble in water; slightly soluble in alcohol; practically insoluble in acetone

• Melting Point: Approximately 180–190°C (varies by source)

Pharmacological Profile:

• Lincomycin HCl acts by inhibiting bacterial protein synthesis through binding to the 50S ribosomal subunit, blocking peptide chain elongation.

• It is active mainly against gram-positive bacteria, some anaerobic bacteria, and Mycoplasma species.

• It is bacteriostatic but can be bactericidal at higher concentrations against susceptible organisms.

• Commonly used to treat penicillin-resistant infections and infections in people allergic to penicillin.

Applications:

• Used as an API to manufacture capsules, oral solutions, injectable preparations, and veterinary formulations.

• Often combined with other antibiotics, e.g., spectinomycin, for synergistic antimicrobial effects in veterinary medicine.

• Effective in treating respiratory tract infections, skin and soft tissue infections, septicemia, osteomyelitis, and other bacterial infections.

Packaging & Storage:

• Typically supplied in 20–25 kg fiber drums, cardboard or paper drums with inner polyethylene lining.

• Should be stored at 2–8°C in a dry, well-closed container, protected from light and moisture to maintain stability.

Quality & Compliance:

• Complies with major pharmacopeia standards including USP, and IP.

• Manufactured under Good Manufacturing Practice (GMP) conditions.

• Available with certificates of analysis (COA), material safety data sheets (MSDS), and regulatory documentation.

Summary Table: Lincomycin Hydrochloride API Powder

Note:
Lincomycin Hydrochloride API is for pharmaceutical manufacturing use only, and as a potent antibiotic it should be handled under appropriate regulatory and quality control standards. 

Erythromycin API Powder is a high-purity pharmaceutical active ingredient widely used in the manufacture of macrolide antibiotic formulations. It is effective against a broad spectrum of Gram-positive and some Gram-negative bacterial infections.

Key Features:

• Chemical Name: Erythromycin

• CAS Number: 114-07-8

• Molecular Formula: C37H67NO13

• Molecular Weight: 733.93 g/mol

• Appearance: White to off-white crystalline powder or granules

• Purity: Typically ≥98% (pharmaceutical grade)

• Solubility: Practically insoluble in water, soluble in ethanol, acetone, and chloroform

• Grades Available: USP/BP/EP/pharmaceutical grade

• Packaging: Usually supplied in 25 kg fiber drums or HDPE containers

Pharmacological Profile:

• Class: Macrolide antibiotic

• Mechanism of Action: Inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thus preventing peptide chain elongation in susceptible bacteria.

• Spectrum: Effective mostly against Gram-positive bacteria (including Streptococcus and Staphylococcus species) and some Gram-negative bacteria and atypical pathogens.

• Therapeutic Uses: Similar to penicillin in clinical use; used to treat respiratory tract infections, skin infections, sexually transmitted infections, and others especially in patients allergic to penicillin.

Applications:

• Bulk intermediate for pharmaceutical manufacturing of tablets, capsules, suspensions, topical creams, and injectables.

• Also utilized in veterinary products and topical formulations.

Storage & Handling:

• Store in a cool, dry place away from light and moisture to prevent degradation.

• Shelf life typically ranges from 2-4 years under appropriate storage.

Summary Table: Erythromycin Powder API

Note:
Erythromycin powder API is intended exclusively for pharmaceutical manufacturing and should be handled under GMP conditions. It must be processed into finished dosage forms before use in clinical settings.

Melatonin Powder IP is a high-purity active pharmaceutical ingredient (API) widely recognized for its role in regulating the body’s natural sleep-wake cycle. Classified as a neurohormone, Melatonin is naturally produced by the pineal gland and plays a crucial role in maintaining circadian rhythm and promoting restful sleep.

Manufactured under stringent GMP conditions, Melatonin Powder IP meets the standards of the Indian Pharmacopoeia (IP), ensuring quality, consistency, and compliance for pharmaceutical and nutraceutical applications. It appears as a white to off-white crystalline powder with excellent stability and solubility characteristics suited for use in tablets, capsules, gummies, and other oral dosage forms.

Melatonin is commonly used in the treatment of insomnia, jet lag, and other sleep disorders, as well as in managing anxiety and improving overall sleep quality. Its antioxidant and chronobiotic properties have also led to its inclusion in formulations aimed at stress relief and immune support.

Ideal for both standalone and combination formulations, Melatonin Powder IP offers reliable bioavailability and patient safety. It is supplied with a comprehensive Certificate of Analysis (COA), MSDS, and stability data, and is securely packaged to preserve potency throughout its shelf life.

Piracetam is a pharmaceutical active ingredient classified as a nootropic agent belonging to the racetam family. It is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA) and is widely used for formulating medicines that address cognitive and neurological disorders.

Key Features

• Chemical Name: 2-Oxo-1-pyrrolidine acetamide (Piracetam)

• CAS Number: 7491-74-9

• Molecular Formula: C6H10N2O2

• Molecular Weight: 142.16 g/mol

• Appearance: White or almost white, odorless, crystalline powder with a slightly bitter taste

• Assay (Purity): 98–102%

• Solubility: Freely soluble in water, soluble in ethanol, insoluble in chloroform and ether

• Melting Point: 151–152 °C

• Grade: Pharmaceutical (IP/BP/EP/USP)

• Packaging: Usually supplied in 25 kg fiber drums for pharmaceutical manufacturing

• Storage Conditions: Store at room temperature, in a dry place, protected from light

Pharmacological Profile

• Class: Nootropic, Central Nervous System Agent

• Mechanism of Action:

  • Enhances neuronal plasticity and cognitive processes by modulating neurochemical transmission, particularly acetylcholine pathways.

  • Increases communication between nerve cells, protects against oxygen deficiency, and improves microcirculation by altering erythrocyte flexibility.

• Therapeutic Category:

  • Classified for use as a cognitive enhancer and neuroprotective agent.

Uses and Indications

• Cognitive Disorders:
  Used in formulating treatments for memory loss, age-related cognitive decline, and learning disabilities such as dyslexia.

• Neurological Disorders:
  Indicated for adjunctive treatment in conditions like myoclonus (especially cortical reflex myoclonus), seizure disorders (epilepsy), vertigo, and tardive dyskinesia.

• Further Applications:
  Sometimes utilized in therapy for Alzheimer's disease, dementia in Parkinson's disease, stroke-related cognitive impairment, head injury, and sickle cell disease (adjunctive use).

• Not FDA Approved for medical or dietary uses in the United States, but prescribed in some other countries for specific neurological indications.

Additional Properties

• Neuroprotective and Anticonvulsant: Offers some protection against neurodegeneration and has been shown to possess anticonvulsant properties.

• Metabolic Enhancer: May improve brain metabolism and increase tolerance to stress or oxygen deficiency.

• Pharmacokinetics: Short plasma half-life (~5 hours), excreted largely through urine.

Safety & Handling

• Shelf Life: 36 months when stored correctly

• Precautions:
  Handle with standard pharmaceutical precautions. Inform healthcare providers of any bleeding disorders or concurrent anticoagulant therapy