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Fexofenadine API Powder is a high-purity active pharmaceutical ingredient used predominantly in the manufacture of modern, non-sedating antihistamine medicines. It is supplied in pharmaceutical grade and is globally recognized for the treatment of allergic conditions.

Key Product Features:

• Chemical Name: Fexofenadine Hydrochloride

• Synonyms: Fexofenadine HCl

• CAS Number: 83799-24-0, alternate CAS numbers such as 153439-40-8 and 138452-21-8 may also be used

• Molecular Formula: C32H39NO4·HCl

• Molecular Weight: 538.13 g/mol

• Appearance: White to off-white crystalline powder

• Grade: Complies with IP, BP, USP, and EP pharmacopeia standards; available in pharmaceutical grade

• Purity: Typically greater than 99%

• Packaging: 25 kg double poly bags in HDPE drums are standard; bulk and custom packaging available

• Storage: Store in a clean, cool, dry area, away from moisture and direct light/heat

Therapeutic Class & Applications:

• Therapeutic Class: Non-sedating antihistamine (second-generation H1 receptor blocker)

• Primary Uses:

  • Treatment of seasonal allergic rhinitis (hay fever)

  • Relief of chronic idiopathic urticaria (hives)

  • Alleviation of symptoms such as sneezing, runny nose, itchy/watery eyes, and itching of the throat or nose

Regulatory & Manufacturing Compliance:

• Manufactured in facilities adhering to WHO-GMP, FDA, DCGI, and international pharmacopeia standards.

• Exported to pharmaceutical companies in more than 90 countries, reflecting a high global reputation and regulatory acceptance.

Mechanism of Action:

• Fexofenadine acts by competitively binding to peripheral H1 histamine receptors, thereby preventing the action of endogenous histamine in the gastrointestinal tract, blood vessels, and bronchial smooth muscle, resulting in relief from allergic symptoms.

Summary Table: Fexofenadine API Powder

Note:
Fexofenadine API powder is strictly for pharmaceutical manufacturing use and requires further processing for safe therapeutic application.

Pyridoxamine Dihydrochloride Powder is the dihydrochloride salt of pyridoxamine, a form of vitamin B6. It appears as a white to slightly brown crystalline powder and is primarily used as an active pharmaceutical ingredient (API), a vitamin standard for analysis, and in research applications.

Key Features:

• Chemical Name: Pyridoxamine dihydrochloride

• Other Names: 4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol dihydrochloride

• CAS Number: 524-36-7

• Molecular Formula: C8H12N2O2·2HCl

• Molecular Weight: 241.11 g/mol

• Appearance: White to slightly brown crystalline powder

• Assay (Purity): ≥98% (commonly 98–99%)

• Solubility: Freely soluble in water, forms a clear, colorless to very faint yellow solution in 5% aqueous solution

• Melting Point: 224–226°C (decomposes)

Properties and Applications:

• Vitamin B6 Activity: Pyridoxamine functions as a form of vitamin B6, similar to pyridoxine and pyridoxal, and is involved in many enzymatic processes and metabolic pathways.

• Antioxidant and Chelating Properties: Its unique structure enables it to scavenge free radicals and chelate metal ions, which helps reduce damage from sugar and lipid degradation products.

• Reference Standard: Used as a reference standard in vitamin analysis.

• Research and Cell Culture: Suitable for mammalian cell culture and research applications.

• Pharmaceutical Grade: Also available as API for potential inclusion in vitamin and nutritional preparations.

• Custom Packaging: Usually supplied in bulk (drums) or small vials depending on use (laboratory or manufacturing).

Stability & Storage:

• Storage Temperature: Store between 2–10°C, in a dry place and protected from light.

• Shelf Life: Stable when stored as recommended.

Drotaverine HCl API Powder is a high-purity active pharmaceutical ingredient widely used in the manufacture of antispasmodic medications. It is valued for its effectiveness in treating smooth muscle spasms across the gastrointestinal, genitourinary, and biliary tracts.

Key Features and Specifications:

• Chemical Name: Drotaverine Hydrochloride

• CAS Number: 985-12-6 (other references: 14009-24-6, 55837-31-3)

• Molecular Formula: C24H32ClNO4 or C24H26N4O4·HCl (depending on reference)

• Molecular Weight: 433.97–434.0 g/mol

• Appearance: White to off-white or pale-yellow crystalline powder

• Purity: Typically ≥99% for API grade

• Solubility: Freely/easily soluble in water, ethanol, and methanol

• Melting Point: 208–210°C

• Storage: Store at 2–8°C, in a dry, well-sealed container, protected from light and moisture

Pharmacological Profile and Main Uses:

• Class: Antispasmodic, selective phosphodiesterase-4 (PDE4) inhibitor

• Mechanism: Inhibits PDE4 enzyme, increasing intracellular cyclic AMP (cAMP), resulting in smooth muscle relaxation. It may also mildly block calcium channels.

• Indications:

  • Relief of spasms in the gastrointestinal tract (including irritable bowel syndrome and inflammatory bowel disease)

  • Spasms of the urinary and biliary tract

  • Dysmenorrhea and uterine spasms

  • Adjunct use for enhancing cervical dilation during childbirth

  • Renal and biliary colic pain control

• Formulations: Used for making tablets, injections, and drops for oral or parenteral administration.

Quality, Compliance, and Handling:

• Grade: Pharmaceutical grade, compliant with BP/EP/USP standards

• Packaging: Typically in 25 kg fiber drums or HDPE drums with double poly bags for moisture protection

• Stability: Sensitive to light and moisture; best retained in tightly sealed containers during storage and transportation

• Synthesis: Produced via synthetic chemical processes in GMP-compliant facilities